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Berne Levy T Bbi Fizyoloji Turkce \/\/FREE\\\\ ❎

Berne Levy T Bbi Fizyoloji Turkce \/\/FREE\\\\ ❎



 
 
 
 
 
 
 

Berne Levy T Bbi Fizyoloji Turkce

First Of Its Kind. berne levy fizyoloji turkce. First Of Its Kind. Seite Index 0
berne levy t bbi fizyoloji turkceWe have recently identified a factor, RAP1-2, that is selectively expressed in B lymphocytes and may induce B cell differentiation. The overall goal of this proposal is to understand the mechanism of RAP1-2 gene expression in B lymphocytes and the function of RAP1-2 in the differentiation of B cells. To address these issues, the following specific aims are proposed: 1) characterize the relationship between the beta, gamma, delta and epsilon chains and RAP1-2 to determine whether RAP1-2 protein is associated with the various non-covalently linked immunoglobulin heavy chains, 2) identify the DNA elements controlling RAP1-2 expression in B lymphocytes and 3) establish the temporal and cellular distribution of RAP1-2 in a developing lymphoid organ. To identify the DNA elements controlling expression of RAP1-2, stably transfected mouse B cells will be used to overproduce each of the four RAP1-2 mRNAs with a functional RAP1-2 protein. The ability of each RAP1-2 mRNA to direct the synthesis of functional proteins will be assessed by transient transfection assays. Additional experiments will use transcriptional and translational molecular probes to determine whether the beta, gamma, delta or epsilon mRNA species are transcribed from the native RAP1-2 gene. To determine the cellular distribution of RAP1-2, mice with a non-inducible RAP1-2 expression system will be used to establish the morphological distribution of RAP1-2 in the developing lymphoid organs. The specificity and expression of RAP1-2 will be determined immunologically. The results of these studies will provide further insight into the factors that regulate B cell development. The proposed research should also yield a better understanding of some B cell malignancies which have been associated with increased expression of RAP1-2, a protein required for the growth of transformed cells.We use cookies to understand how you use our site, give you an awesome experience, and deliver our services. By using our site, you acknowledge that you have read and agree to our Privacy Policy and Terms of Use

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